March 1, 2003Psychosomatic Medicine
Effects of Depression on QT Interval Variability After Myocardial Infarction
Key result
Major depression in patients recovering from a recent myocardial infarction was associated with significantly greater QT interval variability compared to nondepressed matched controls.
Why the study?
Is major depression associated with increased QT interval variability in patients recovering from myocardial infarction?
Population
40 patients recovering from a recent myocardial infarction
Comparison
Major depression (exposure) vs Nondepressed (matched on age and sex)
Design
Cohort
Follow-up
24 hours
Authors
Discussion
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Implication
May signal heightened arrhythmic risk post-MI; leaves open whether depression treatment reduces QT variability.
Study Design
Type
Observational (n=40)
Structured PICO
Is major depression associated with increased QT interval variability in patients recovering from myocardial infarction?
P
Population
40 patients recovering from a recent myocardial infarction (20 with major depression, 20 nondepressed matched on age and sex)
I
Intervention
Major depression (exposure)
C
Comparator
Nondepressed (matched on age and sex)
O
Outcome
QT interval variability on 24-hour Holter monitoringsurrogate
Major depression in post-myocardial infarction patients is associated with increased QT interval variability, suggesting a potential mechanism for increased sudden cardiac death risk.
Cite This Study
Carney et al. (2003) conducted an observational in Myocardial infarction and major depression (n=40). Major depression vs. Nondepressed was evaluated on QT interval variability. Major depression in patients recovering from a recent myocardial infarction was associated with significantly greater QT interval variability compared to nondepressed matched controls.