Why the study?
The relationship between aortic valve sclerosis and heart failure prognosis was poorly studied.
Does the presence or development of aortic valve sclerosis predict all-cause mortality and cardiovascular outcomes in patients with heart failure?
Population
1397 HF patients
Comparison
Presence or development of AV sclerosis vs absence of AV sclerosis
Design
Cohort study
Follow-up
5 years
Key result
Development of aortic valve sclerosis in heart failure patients was strongly associated with increased all-cause mortality (HR 3.4; 95% CI 1.3-10.8; P=0.017).
Authors
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May signal higher mortality risk warranting closer HF surveillance; leaves open its value for risk stratification or as a therapeutic target.
Cohort (n=1,397)
Does the presence or development of aortic valve sclerosis predict all-cause mortality and cardiovascular outcomes in patients with heart failure?
Effect estimate: HR 3.4 (95% CI 1.3-10.8)
p-value: p=0.017
In heart failure patients, the development of aortic valve sclerosis serves as a marker of disease progression and is strongly associated with increased all-cause mortality and cardiovascular outcomes.
Myasoedova et al. (2025) conducted a cohort in Heart failure (n=1,397). Aortic valve (AV) sclerosis development vs. No AV sclerosis development was evaluated on All-cause mortality (HR 3.4, 95% CI 1.3-10.8, p=0.017). Development of aortic valve sclerosis in heart failure patients was strongly associated with increased all-cause mortality (HR 3.4; 95% CI 1.3-10.8; P=0.017).