Key result
CMR left atrial emptying fraction predicts ~4% higher HF and mortality risk per percent change.
Why the study?
The relations of left atrial features to diastolic dysfunction severity and adverse clinical outcomes remained unclear using CMR images.
Do left atrial indices assessed by CMR predict adverse clinical outcomes in patients with left ventricular diastolic dysfunction?
Population
32 normal controls and 132 patients with diastolic dysfunction
Comparison
Normal controls vs grade I DD (n = 69) vs grade II DD (n = 42) vs grade III DD (n = 21)
Follow-up
Average 36-months
Authors
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May support CMR LAEF for prognostication in diastolic dysfunction; hypothesis-generating and should not yet alter practice.
Cohort (n=164)
No
Do left atrial indices assessed by CMR predict adverse clinical outcomes in patients with left ventricular diastolic dysfunction?
Effect estimate: HR 1.04 (95% CI 1.02-1.06)
p-value: p=<0.001
Nguyen et al. (2021) conducted a cohort in Left ventricular diastolic dysfunction (n=164). Cardiac magnetic resonance imaging of left atrial parameters vs. Normal controls was evaluated on Composite of hospital admissions for heart failure and all-cause mortality (HR 1.04, 95% CI 1.02-1.06, p=<0.001). Left atrial emptying fraction assessed by CMR was an independent predictor of heart failure admission and all-cause mortality in patients with diastolic dysfunction (HR 1.04 per 1% change).
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