Key result
The AT1R gene A(1166)C polymorphism was not associated with essential hypertension in 108 cases and 102 controls, but the C(1166) allele was linked to early-onset hypertension in males.
Why the study?
Is the AT1R gene A(1166)C polymorphism associated with essential hypertension in the Jordanian population?
Population
108 hypertensive individuals and 102 age- and gender-matched non-hypertensive controls of the Jordanian…
Comparison
Angiotensin II type 1 receptor gene AC variant… vs Non-carriers / A(1166) allele
Design
Case-control
Authors
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No overall association in Jordanians; leaves open possible male-specific link to early-onset hypertension needing confirmation.
Case-Control (n=210)
No
Is the AT1R gene A(1166)C polymorphism associated with essential hypertension in the Jordanian population?
The AT1R gene A(1166)C polymorphism is not associated with essential hypertension overall in Jordanians, but is linked to early-onset hypertension in males and high waist circumference.
Shahin et al. (2013) conducted a case-control in Essential hypertension (n=210). AT1R gene A(1166)C polymorphism vs. Non-hypertensive controls was evaluated on Distribution of alleles and genotypes between hypertensive and non-hypertensive individuals. The AT1R gene A(1166)C polymorphism was not associated with essential hypertension in 108 cases and 102 controls, but the C(1166) allele was linked to early-onset hypertension in males.
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