Key result
Black children had a significantly higher frequency of the T235 allele of the angiotensinogen gene (0.81 vs 0.42) and 19% higher serum angiotensinogen levels compared to white children.
Population
210 normotensive children (148 white and 62 black), mean age 14.8 years.
Design
Cohort
Authors
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May inform early BP disparity mechanisms; extends AGT-hypertension associations but remains hypothesis-generating in observational data.
Cross-Sectional (n=213)
No
Absolute Event Rate: 0.81% vs 0.42%
p-value: p=0.0001
Racial differences in the renin-angiotensin system, specifically higher T235 allele frequency and angiotensinogen levels in black children, may contribute to disparities in blood pressure development.
Bloem et al. (1995) conducted a cross-sectional in Normotensive (n=213). Black race vs. White race was evaluated on Frequency of the T235 allele (p=0.0001). Black children had a significantly higher frequency of the T235 allele of the angiotensinogen gene (0.81 vs 0.42) and 19% higher serum angiotensinogen levels compared to white children.
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