Key result
A systematic review of 155 studies on adverse drug reactions to heart failure medications found that only 11 (7%) reported sex-stratified data, highlighting a severe lack of evidence for women.
Why the study?
Women are more likely to experience adverse drug reactions than men, but little is known about adverse drug reactions in women with heart failure treated with guideline-recommended drugs.
Are there sex differences in adverse drug reactions to guideline-recommended heart failure drugs?
Population
155 eligible records of women and men with HF
Comparison
Sex differences in ADRs to guideline-recommended HF medications
Design
Systematic review
Authors
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Clinicians lack sex-specific ADR data for HF drugs in women; this gap leaves open questions on differential risks and requires stratified reporting in trials.
Systematic Review
Are there sex differences in adverse drug reactions to guideline-recommended heart failure drugs?
There is a severe lack of sex-stratified reporting for adverse drug reactions to heart failure medications, highlighting a critical gap in evidence for treating women with HF.
Bots et al. (2019) conducted a systematic review in Heart failure. Guideline-recommended heart failure drugs vs. Men (sex-stratified reporting) was evaluated on Sex differences in adverse drug reactions. A systematic review of 155 studies on adverse drug reactions to heart failure medications found that only 11 (7%) reported sex-stratified data, highlighting a severe lack of evidence for women.
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