Key result
Poor functional capacity in late survivors of partial left ventriculectomy was associated with altered postoperative LV geometry, including lower late left ventricular ejection fraction (P=0.006).
Why the study?
Does left ventricular geometry and performance correlate with functional capacity late after partial left ventriculectomy in patients with non-ischemic dilated cardiomyopathy?
Cohort (n=17)
Does left ventricular geometry and performance correlate with functional capacity late after partial left ventriculectomy in patients with non-ischemic dilated cardiomyopathy?
p-value: p=0.04
Poor functional capacity in late survivors of partial left ventriculectomy for non-ischemic dilated cardiomyopathy is related to postoperative left ventricular geometry.
Altered LV geometry may underlie poor late function after PLV; hypothesis-generating and should not yet change practice.
OBJECTIVES: While partial left ventriculectomy (PLV) may improve functional status, the duration and determinants of this improvement are poorly known. This study sought to assess the relationship between left ventricular (LV) shape and function and functional status in late survivors after PLV for non-ischemic dilated cardiomyopathy (DCM). METHODS: We assessed the relations between LV shape and function and functional status in 17 consecutive patients who survived >12 months after PLV for non-ischemic DCM. Invasive diagnostic studies were performed before, early after, at mid-term after, and late after PLV. According to their functional status after >12 months of follow-up, patients were divided into responders (n=10) or non-responders (n=7). RESULTS: After PLV, the LV systolic major-to-minor axis ratio was higher in responders at early, mid-, and late follow-up (P=0.003, P=0.008 and P=0.04, respectively). LV circumferential end-diastolic stress decreased early after PLV, but increased afterwards in non-responders only (P=0.049). LV ejection fraction was similar in the two groups at baseline, and at early and mid-follow-up, but was lower in non-responders at late follow-up (P=0.006). However, LV end-diastolic and end-systolic volumes, and LV end-systolic circumferential stress showed no difference between the two groups. CONCLUSIONS: It appears that poor functional capacity in late post-PLV survivors is related to postoperative LV geometry.
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Popović et al. (2001) conducted a cohort in Non-ischemic dilated cardiomyopathy (n=17). Partial left ventriculectomy vs. Responders vs non-responders was evaluated on LV systolic major-to-minor axis ratio at late follow-up (p=0.04). Poor functional capacity in late survivors of partial left ventriculectomy was associated with altered postoperative LV geometry, including lower late left ventricular ejection fraction (P=0.006).
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