Key result
Partial left ventriculectomy significantly increased mean left ventricular end systolic elastance from 0.52 to 1.47 mm Hg/ml (p=0.0004) and improved ventriculoarterial coupling.
Why the study?
Does partial left ventriculectomy improve left ventricular end systolic elastance and ventriculoarterial coupling in patients with idiopathic dilated cardiomyopathy?
Observational (n=22)
Does partial left ventriculectomy improve left ventricular end systolic elastance and ventriculoarterial coupling in patients with idiopathic dilated cardiomyopathy?
Partial left ventriculectomy significantly improves left ventricular end systolic elastance and ventriculoarterial coupling in patients with idiopathic dilated cardiomyopathy.
Answers are grounded in this paper and cite their sources.
Supports partial left ventriculectomy in idiopathic dilated cardiomyopathy; leaves open need for randomized outcome trials.
OBJECTIVE: To assess the effect of partial left ventriculectomy (PLV) on estimate of left ventricular end systolic elastance (Ees), arterial elastance, and ventriculoarterial coupling. PATIENTS: 11 patients with idiopathic dilated cardiomyopathy before and two weeks after PLV, and 11 controls. INTERVENTIONS: Single plane left ventricular angiography with simultaneous measurements of femoral artery pressure was performed during right heart pacing before and after load reduction. RESULTS: PLV increased mean (SD) Ees from 0.52 (0.27) to 1.47 (0.62) mm Hg/ml (p = 0.0004). The increase in Ees remained significant after correction for the change in left ventricular mass (p = 0.004) and end diastolic volume (p = 0.048). As PLV had no effect on arterial elastance, ventriculoarterial coupling improved from 3.25 (2.17) to 1.01 (0.93) (p = 0.017), thereby maximising left ventricular stroke work. CONCLUSION: It appears that PLV improves both Ees and ventriculoarterial coupling, thus increasing left ventricular work efficiency.
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Popović et al. (2000) conducted an observational in Idiopathic dilated cardiomyopathy (n=22). Partial left ventriculectomy (PLV) vs. Baseline (before PLV) and controls was evaluated on Left ventricular end systolic elastance (Ees) (p=0.0004). Partial left ventriculectomy significantly increased mean left ventricular end systolic elastance from 0.52 to 1.47 mm Hg/ml (p=0.0004) and improved ventriculoarterial coupling.
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