Why the study?
Does partial left ventriculectomy improve acute cardiac function in patients with end-stage dilated cardiomyopathy?
Does partial left ventriculectomy improve acute cardiac function in patients with end-stage dilated cardiomyopathy?
Partial left ventriculectomy acutely improves intraoperative hemodynamics, including cardiac output and contractility, in patients with end-stage dilated cardiomyopathy.
Answers are grounded in this paper and cite their sources.
Acute hemodynamic gains with PLV in end-stage DCM are hypothesis-generating; prospective trials needed before clinical adoption.
Partial left ventriculectomy (PLV) has been introduced as an alternative surgical therapy for patients with end‐stage dilated cardiomyopathy. The physiological benefits of PLV are relatively unknown. Therefore, the objective of this study was to determine the acute effects of PLV by measuring cardiac function before and after PLV. Aortic and left ventricular pressures and aortic flow were measured in eight patients. Continuous, beat‐to‐beat data were recorded and compared pre‐PLV and post‐PLV with and without inferior vena cava (IVC) occlusions. PLV increased cardiac output (0.93 ± 0.5, p = 0.01) as a result of increased stroke volume (5.12 ± 4.24, p = 0.06) and heart rate (14.5 ± 8.44, p = 0.02). Contractility (± dP/dt, 240.33 ± 74.28, p = 0.001) and external work (650.8 ± 320.4, p = 0.01) were also improved. Left ventricular end‐diastolic elastance (0.15 ± 0.14, p = 0.10) nearly doubled after PLV. Our results indicated an improved cardiac function as measured by increased cardiac output, stroke volume, ejection fraction (EF), and contractility.
No takes yet. Share an insight, caveat, or question.
Koenig et al. (1985) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: