Key result
Leukocyte depletion as an adjunct to terminal blood cardioplegia significantly improved ultrastructural recovery and reduced myocardial damage compared to whole blood or terminal cardioplegia alone.
Why the study?
Does leukocyte depletion as an adjunct to terminal blood cardioplegia attenuate reperfusion injury in patients with left ventricular hypertrophy undergoing aortic valve replacement?
Population
30 patients with left ventricular hypertrophy undergoing aortic valve replacement.
Comparison
Leukocyte depletion as an adjunct to terminal… vs Whole blood reperfusion or terminal blood…
Design
RCT, Randomized into one of three groups
Follow-up
15 minutes after reperfusion (for biopsies)
Authors
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Supports leukocyte-depleted terminal cardioplegia in severe LVH AVR; extends myocardial protection strategies against reperfusion injury.
RCT (n=30)
Randomized into three groups
Does leukocyte depletion as an adjunct to terminal blood cardioplegia attenuate reperfusion injury in patients with left ventricular hypertrophy undergoing aortic valve replacement?
Leukocyte-depleted terminal blood cardioplegia attenuates myocardial reperfusion injury and improves clinical parameters in patients with severe LVH undergoing surgical aortic valve replacement.
Sawa et al. (1996) conducted an RCT in Left ventricular hypertrophy undergoing aortic valve replacement (n=30). Leukocyte depletion as an adjunct to terminal blood cardioplegia (LDTC) vs. Whole blood (WB) and Terminal blood cardioplegia (TC) was evaluated on Ultrastructural alterations (myocyte and endothelial cell damage). Leukocyte depletion as an adjunct to terminal blood cardioplegia significantly improved ultrastructural recovery and reduced myocardial damage compared to whole blood or terminal cardioplegia alone.
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