Key result
Minimally invasive ascending aorta coarctation in rabbits produced myocardial hypertrophy with a low animal mortality rate of 5% and decreased diastolic and systolic function compared to control.
Authors
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Enables efficient preclinical modeling of hypertrophy; extends low-mortality rabbit models for cardiovascular research.
Martins et al. (2001) studied Myocardial hypertrophy. Minimally invasive ascending aorta coarctation vs. Control was evaluated on Morphometric and hemodynamic parameters (Left ventricular weight/body weight ratio and muscle area). Minimally invasive ascending aorta coarctation in rabbits produced myocardial hypertrophy with a low animal mortality rate of 5% and decreased diastolic and systolic function compared to control.
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