Key result
Mathematical models of canine right and left atria cardiomyocytes successfully reproduced experimental data on action potential morphology, rate dependence, and duration restitution.
The developed mathematical models of canine right and left atria cardiomyocytes successfully reproduce regional action potential characteristics, providing a tool for future simulations of whole heart excitation and arrhythmias.
Validated canine atrial models enable in silico arrhythmia studies; extends computational tools but leaves open human translation.
The aim of this study is to build two mathematical models of canine ionic currents specific to right atria and left atria. The canine left atria mathematical model was firstly modified from the Ramirez-Nattel-Courtemanche (RNC) model using the recently available experimental data of ionic currents and was further developed based on our own experimental data. A model of right atria was then built by considering the differences between right atria and left atria. The two developed models well reproduced the experimental data on action potential morphology, the rate dependence, and action potential duration restitution. They are useful for investigating the mechanisms underlying the heterogeneity of canine regional action potentials and would help the simulation of whole heart excitation propagation and cardiac arrhythmia in the near future.
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Xia et al. (2010) studied Canine atrial electrophysiology. Mathematical models of canine right and left atria cardiomyocytes was evaluated on Action potential morphology, rate dependence, and action potential duration restitution. Mathematical models of canine right and left atria cardiomyocytes successfully reproduced experimental data on action potential morphology, rate dependence, and duration restitution.
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