Key result
Biventricular pacing provides morbidity and mortality benefits in drug-refractory heart failure, though challenges remain in diagnosing ventricular dyssynchrony and optimizing pacemaker programming.
Why the study?
Does biventricular pacing improve morbidity and mortality in patients with drug-refractory heart failure?
Does biventricular pacing improve morbidity and mortality in patients with drug-refractory heart failure?
This review highlights the principles, current evidence, and future challenges of biventricular pacing in managing drug-refractory heart failure.
May support biventricular pacing in refractory HF; leaves open refined dyssynchrony diagnostics and programming optimization.
Biventricular pacing has been an exciting recent advance in the management of drug-refractory heart failure. This new therapy has evolved as much from necessity as scientific observation, since benefits derived from pharmacotherapy currently appear to have reached their peak. Clinical trials of biventricular pacing are establishing morbidity and mortality benefits in heart failure. New challenges in the use of these pacemakers are now arising. These include the accurate diagnosis of ventricular dyssynchrony and, hence, potential responders to the refinement of implantation of the left ventricular lead to the appropriate dyssynchronous ventricular area and optimization of pacemaker programming. This review gives a general overview of the principles and the current evidence for the use of biventricular pacemakers in the treatment of heart failure. In addition, a discussion of current research and future projects is included.
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Gould et al. (2006) conducted a review in Heart failure. Biventricular pacing was evaluated. Biventricular pacing provides morbidity and mortality benefits in drug-refractory heart failure, though challenges remain in diagnosing ventricular dyssynchrony and optimizing pacemaker programming.
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