Key result
Structural and functional echocardiographic parameters of subclinical cardiac dysfunction were independently associated with higher pulmonary artery systolic pressure, including a 1.27 mmHg increase per 1-SD increase in E/E' ratio.
Why the study?
Are structural and functional echocardiographic parameters of subclinical cardiac dysfunction associated with pulmonary arterial pressures in the general ageing population?
Cross-Sectional (n=2,592)
No
Are structural and functional echocardiographic parameters of subclinical cardiac dysfunction associated with pulmonary arterial pressures in the general ageing population?
Effect estimate: 1.27 mmHg per 1-SD increase in E/E' ratio (95% CI 0.92-1.61)
p-value: p=<0.001
In an unselected ageing population, structural and functional echocardiographic parameters of subclinical left heart dysfunction are independently associated with higher pulmonary arterial pressures.
May inform pulmonary pressure risk stratification in ageing adults; leaves open causal and interventional implications.
Pulmonary hypertension is associated with increased mortality and morbidity in the elderly population. Heart failure is a common cause of pulmonary hypertension. Yet, the relation between left heart parameters reflective of subclinical cardiac dysfunction and increased filling pressures, and pulmonary arterial pressures in the elderly population remains elusive. Within the population-based Rotterdam Study, 2592 unselected participants with a mean age of 72.6 years (61.4% women) had complete echocardiography data available. We studied the cross-sectional associations of left heart structure and systolic and diastolic function with echocardiographically measured pulmonary artery systolic pressure. Mean pulmonary artery systolic pressure was 25.4 mmHg. After multivariable-adjustment measures of both structure and function were independently associated with pulmonary artery systolic pressure: E/A ratio [0.63 mmHg (95% CI 0.35-0.91) per 1-SD increase], left atrial diameter [0.79 mmHg (0.50-1.09) per 1-SD increase], E/E' ratio [1.27 mmHg (0.92-1.61) per 1-SD increase], left ventricular volume [0.62 mmHg (0.25-0.98) per 1-SD increase], fractional shortening [0.45 mmHg (0.17-0.74) per 1-SD increase], aortic root diameter [- 0.43 mmHg (- 0.72 to - 0.14) per 1-SD increase], mitral valve deceleration time [- 0.31 mmHg (- 0.57 to - 0.05) per 1-SD increase], and E' [1.04 mmHg (0.66-1.42) per 1-SD increase]. Results did not materially differ when restricting the analyses to participants free of symptoms of shortness of breath. Structural and functional echocardiographic parameters of subclinical cardiac dysfunction and increased filling pressures are associated with pulmonary arterial pressures in the unselected general ageing population.
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Billar et al. (2017) conducted a cross-sectional in General ageing population (n=2,592). Echocardiographic parameters of left heart structure and function was evaluated on Echocardiographically measured pulmonary artery systolic pressure (ePASP) (1.27 mmHg per 1-SD increase in E/E' ratio, 95% CI 0.92-1.61, p=<0.001). Structural and functional echocardiographic parameters of subclinical cardiac dysfunction were independently associated with higher pulmonary artery systolic pressure, including a 1.27 mmHg increase per 1-SD increase in E/E' ratio.
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