Key result
Time in therapeutic range (TTR) is a complex metric with multiple calculation methods, and reporting additional parameters such as the percentage of out-of-range values is recommended to improve intertrial comparisons.
The author proposes that reporting additional INR parameters alongside TTR is necessary to accurately compare anticoagulation management and outcomes across clinical trials.
Anticoagulation with warfarin has been used for over 60 years; however, its administration is fraught with difficulty since many factors can affect warfarin dosing. The concept of time in therapeutic range (TTR) has become a popular way to report warfarin management and compare anticoagulation management across clinical trials. However, TTR is a much more complex concept than most clinicians and trialists recognize. This manuscript attempts to discuss some of the important factors underlying this complexity and presents a suggestion to improve reports on TTR.
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James A. Reiffel (2017) conducted a review in Atrial fibrillation. Warfarin was evaluated. Time in therapeutic range (TTR) is a complex metric with multiple calculation methods, and reporting additional parameters such as the percentage of out-of-range values is recommended to improve intertrial comparisons.
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