Key result
Having >4 children is linked to ~24% higher incident heart failure risk versus 1-2 children.
Why the study?
Comprehensive evaluations of woman-specific risk factors in relation to incident heart failure are limited.
Do female reproductive factors affect the risk of incident heart failure in women without prevalent HF?
Population
229,026 women without prevalent HF from the UK Biobank cohort
Comparison
Self-reported female reproductive factors
Design
Prospective cohort study
Follow-up
Until December 2020
Authors
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Parity >4 was associated with higher HF risk; hypothesis-generating and requires prospective confirmation before informing risk assessment.
Cohort (n=229,026)
Do female reproductive factors affect the risk of incident heart failure in women without prevalent HF?
Effect estimate: HR 1.24 (95% CI 1.05-1.47)
Female reproductive history, specifically higher parity and history of stillbirths, is associated with an increased risk of incident heart failure.
Zhu et al. (2023) conducted a cohort in Incident heart failure (n=229,026). Female reproductive factors (parity, stillbirths) vs. Women with 1 or 2 children, or no stillbirth was evaluated on Incident heart failure (HR 1.24, 95% CI 1.05-1.47). Having >4 children was associated with a higher risk of incident heart failure compared to having 1 or 2 children (HR 1.24; 95% CI 1.05-1.47).
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