September 1, 1993Journal of Magnetic Resonance Imaging
Flow velocity quantification in human coronary arteries with fast, breath‐hold MR angiography
Why the study?
Can breath-hold magnetic resonance (MR) angiography noninvasively quantify flow velocities in human coronary arteries?
Population
15 subjects and flow phantoms
Design
Cross-sectional
Authors
Discussion
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Implication
May enable noninvasive coronary flow assessment; leaves open validation and clinical utility in larger studies.
Key Points
- To implement and evaluate a fast, breath-hold magnetic resonance (MR) angiography technique for depicting coronary arteries and noninvasively measuring coronary flow velocities.
- Tested the breath-hold MR angiography velocity quantification technique in flow phantoms.
- Evaluated coronary flow velocities in human subjects: 11 subjects imaged at rest and 4 subjects imaged before and during pharmacologic stress induced by intravenous adenosine.
- Resting flow velocity was 9.9 ± 3.5 cm/sec in the mid-right coronary artery (n = 12) and significantly higher at 20.5 ± 5.2 cm/sec in the proximal left anterior descending coronary artery (n = 6).
- Coronary flow velocities typically increased at least fourfold during intravenous adenosine-induced stress.
Structured PICO
Can breath-hold magnetic resonance (MR) angiography noninvasively quantify flow velocities in human coronary arteries?
P
Population
15 subjects (11 studied at rest, 4 studied before and during pharmacologic stress induced by intravenous adenosine) and flow phantoms
I
Intervention
Breath-hold magnetic resonance (MR) angiography
O
Outcome
Coronary artery flow velocitiessurrogate
Noninvasive measurement of coronary artery flow velocities is feasible with breath-hold MR angiography and can detect flow increases during pharmacologic stress.
Cite This Study
Edelman et al. (1993) studied this question.