July 1, 2003Psychosomatic Medicine
Hostility, Social Support, and Adrenergic Receptor Responsiveness Among African-American and White Men and Women
Key result
High hostility and low satisfaction with social support were associated with reduced cardiac beta-adrenergic receptor responsiveness among men and women.
Why the study?
Are hostility and social support associated with adrenergic receptor responsiveness in African American and white men and women?
Population
149 African American and white men and women, aged 25 to 45 years with SBP < 160 and DBP < 105.
Design
Cross-sectional
Authors
Discussion
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Implication
Hypothesis-generating for psychosocial effects on cardiac signaling; prospective studies needed before clinical relevance.
Study Design
Type
Cross-Sectional (n=149)
Structured PICO
Are hostility and social support associated with adrenergic receptor responsiveness in African American and white men and women?
P
Population
149 African American and white men and women, aged 25 to 45 years with SBP < 160 and DBP < 105.
I
Intervention
Hostility and social support assessment (evaluated alongside isoproterenol and phenylephrine challenges)
O
Outcome
Beta-adrenergic and alpha-adrenergic receptor responsivenesssurrogate
High hostility and low social support are associated with reduced beta-adrenergic receptor responsiveness, suggesting a potential physiological mechanism linking psychosocial factors to increased cardiovascular disease risk.
Cite This Study
Hughes et al. (2003) conducted a cross-sectional in Cardiovascular risk factors (n=149). Hostility and social support was evaluated on Beta-adrenergic and alpha-adrenergic receptor responsiveness. High hostility and low satisfaction with social support were associated with reduced cardiac beta-adrenergic receptor responsiveness among men and women.