September 1, 1993American Journal of Hypertension
Responsiveness to - and -Adrenergic Receptor Agonists Effects of Race in Borderline Hypertensive Compared to Normotensive Men
Why the study?
Does adrenergic receptor responsiveness differ by race in borderline hypertensive compared to normotensive men?
Population
26 men (13 black and 13 white), borderline hypertensive and normotensive, matched for age and body mass
Comparison
Intravenous isoproterenol and phenylephrine to… vs Normotensive controls and cross-racial comparison
Design
Cross-sectional
Authors
Discussion
Loading...
Member takes
Implication
Racial differences in adrenergic responsiveness may contribute to hypertension pathogenesis; hypothesis-generating and should not yet change practice.
Key Points
- To determine whether race influences alpha- and beta-adrenergic receptor responsiveness in borderline hypertensive men compared to normotensive controls.
- Evaluated 13 Black and 13 White men classified as either borderline hypertensive or normotensive, matched for age and body mass.
- Assessed cardiac beta-adrenergic and vascular beta 2-adrenergic sensitivity using intravenous isoproterenol.
- Measured vascular alpha 1-adrenergic receptor sensitivity via the pressor response to intravenous phenylephrine.
- White borderline hypertensive men exhibited significantly decreased responsiveness of cardiac beta-adrenergic and vascular beta 2-adrenergic receptors to isoproterenol compared to normotensive controls.
- Black borderline hypertensive men showed no evidence of decreased beta-adrenergic receptor responsiveness.
- Vascular alpha 1-adrenergic receptor responsiveness was unrelated to blood pressure status but was significantly higher in Black men than in White men.
Structured PICO
Does adrenergic receptor responsiveness differ by race in borderline hypertensive compared to normotensive men?
P
Population
26 men (13 black and 13 white), borderline hypertensive and normotensive, matched for age and body mass
I
Intervention
Intravenous isoproterenol and phenylephrine to assess adrenergic receptor responsiveness
C
Comparator
Normotensive controls and cross-racial comparison (black vs white)
O
Outcome
Responsiveness of cardiac beta-adrenergic, vascular beta 2-adrenergic, and vascular alpha 1-adrenergic receptorssurrogate
Racial differences in alpha- and beta-adrenergic receptor responsiveness may play a role in the pathogenesis of hypertension.
Limitations
- Small sample size (preliminary observations)
Cite This Study
Sherwood et al. (1993) studied this question.