Key result
Black young men exhibited higher total peripheral resistance responses to behavioral stress and greater diminution in inotropic myocardial responses after propranolol compared to White young men.
Why the study?
Does propranolol alter hemodynamic responses to behavioral stress differently in young Black and White men with and without marginal systolic BP elevations?
Population
40 young men, including 11 with marginal systolic BP elevations and 29 with normal BP.
Comparison
Infusion of the nonselective beta-antagonist… vs Infusion of saline placebo during the same task.
Design
Other
Authors
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Racial differences in stress hemodynamics may exist; leaves open whether propranolol effects vary by race in borderline hypertension.
Does propranolol alter hemodynamic responses to behavioral stress differently in young Black and White men with and without marginal systolic BP elevations?
Black men exhibit different hemodynamic responses to behavioral stress compared to White men, characterized by higher total peripheral resistance and greater sensitivity to beta-blockade in myocardial responses.
Light et al. (1989) studied Borderline hypertension (n=40). Propranolol infusion vs. Saline placebo was evaluated on Blood pressure and hemodynamic responses (cardiac output and total peripheral resistance) to a competitive reaction-time task. Black young men exhibited higher total peripheral resistance responses to behavioral stress and greater diminution in inotropic myocardial responses after propranolol compared to White young men.
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