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March 1, 1991AJP Cell Physiology

Uncoupling of cardiac cells by fatty acids: structure-activity relationships

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Population

Pairs of neonatal rat heart cells

Design

Preclinical

Authors

JBJanis M. BurtUniversity of ArizonaKMKenneth MasseyUniversity of ArizonaBMB. N. MinnichUniversity of Arizona

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Implication

May link oleic acid to ischemic arrhythmias; hypothesis-generating for human gap junction studies.

Structured PICO

P
Population
Pairs of neonatal rat heart cells
I
Intervention
Oleic acid, other unsaturated fatty acids (C-18: cis 6, 9, or 11, and C-18, 16, and 14, cis 9), saturated fatty acids (C-10, 12, and 14), and saturated fatty alcohols (C-8, 10, and 12)
O
Outcome
Permeability and conductance of gap junctions (cellular uncoupling)surrogate

Free fatty acids such as oleic acid rapidly uncouple cardiac gap junctions, providing a potential mechanism for the initiation of arrhythmias during and after ischemic insults.

Cite This Study

Burt et al. (1991) studied this question.

synapsesocial.com/papers/6a16411da2d9d2b88ec50d60https://doi.org/10.1152/ajpcell.1991.260.3.c439
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Single-channel events and gating behavior of the cardiac gap junction channel.1988 · 201 citations
  2. 2Electrophysiological effects of amphiphiles on canine purkinje fibers. Implications for dysrhythmia secondary to ischemia.1981 · 133 citations
  3. 3Volatile anesthetics block intercellular communication between neonatal rat myocardial cells.1989 · 179 citations
  4. 4The Effects of Drugs on Membrane Fluidity1984 · 298 citations
  5. 5Direct modulation of secretory chloride channels by arachidonic and other cis unsaturated fatty acids.1990 · 135 citations