Key result
Antihypertensive therapy did not significantly reduce the risk of developing renal dysfunction in patients with non-malignant hypertension (RR 0.97; 95% CI 0.78-1.21; P=0.77).
Why the study?
Does antihypertensive therapy prevent the development of renal insufficiency in patients with non-malignant hypertension?
Population
Patients with non-malignant hypertension
Comparison
Antihypertensive drug therapy vs No antihypertensive therapy or less-intensive…
Design
Review
Authors
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Does not support antihypertensives to prevent renal dysfunction in non-malignant hypertension; challenges consensus and leaves open independent causality.
Does antihypertensive therapy prevent the development of renal insufficiency in patients with non-malignant hypertension?
Effect estimate: RR 0.97 (95% CI 0.78-1.21)
p-value: p=0.77
Current evidence provides weak support for the thesis that non-malignant hypertension is an independent de-novo cause of renal insufficiency.
Chi‐yuan Hsu (2002) conducted a review in Non-malignant hypertension. Antihypertensive drug therapy vs. Control or less-intensive therapy was evaluated on Developing renal dysfunction (RR 0.97, 95% CI 0.78-1.21, p=0.77). Antihypertensive therapy did not significantly reduce the risk of developing renal dysfunction in patients with non-malignant hypertension (RR 0.97; 95% CI 0.78-1.21; P=0.77).
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