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Troponin exhibits non-canonical roles and aberrant expression patterns beyond the sarcomere, with implications in cancer, cardiomyopathy, and skeletal muscle aging.
Troponin has emerging non-canonical roles beyond regulating striated muscle contraction, with implications in cancer, cardiomyopathy, and aging.
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Broadens troponin interpretation in cancer and aging; leaves open clinical translation and mechanistic validation.
// Jamie R. Johnston 1 , P. Bryant Chase 2 and Jose Renato Pinto 1 1 Department of Biomedical Sciences, The Florida State University College of Medicine, Tallahassee, FL, 32306-4300, USA 2 Department of Biological Science, The Florida State University, Tallahassee, FL, 32306-4370, USA Correspondence to: Jose Renato Pinto, email: jose.pinto@med.fsu.edu Keywords: cancer; troponin; striated muscle; nucleus; cardiomyopathy Received: September 06, 2017 Accepted: November 20, 2017 Published: December 04, 2017 ABSTRACT Troponin is a heterotrimeric Ca 2+ -binding protein that has a well-established role in regulating striated muscle contraction. However, mounting evidence points to novel cellular functions of troponin, with profound implications in cancer, cardiomyopathy pathogenesis and skeletal muscle aging. Here, we highlight the non-canonical roles and aberrant expression patterns of troponin beyond the sarcomeric milieu. Utilizing bioinformatics tools and online databases, we also provide pathway, subcellular localization, and protein-protein/DNA interaction analyses that support a role for troponin in multiple subcellular compartments. This emerging knowledge challenges the conventional view of troponin as a sarcomere-specific protein exclusively involved in muscle contraction and may transform the way we think about sarcomeric proteins, particularly in the context of human disease and aging.
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Johnston et al. (2017) conducted a review in Cancer, cardiomyopathy, and skeletal muscle aging. Troponin was evaluated. Troponin exhibits non-canonical roles and aberrant expression patterns beyond the sarcomere, with implications in cancer, cardiomyopathy, and skeletal muscle aging.
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