Key result
A 10-compartment model of the coronary arterial tree showed that larger vessels attenuate smaller vessel myogenic activity, with maximum perfusion pressure effects occurring in vessels 123-181 µm.
A computational model of the coronary arterial tree demonstrates that myogenic responsiveness is sufficient to achieve autoregulation and that larger vessels attenuate the myogenic activity of smaller vessels.
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Remains hypothesis-generating in a computational model; extends coronary autoregulation insights but requires in vivo validation.
The objectives of this study were to evaluate the myogenic behavior of blood vessels and their interaction within the coronary arterial tree and to evaluate the possible role of the myogenic response in autoregulation. The model consists of 10 compartments in series, each representing a class of vessel sizes. Diameter and resistance in each class are determined by their value at full dilation (d(p,) R(p)) and by the myogenic response. Three distributions of R(p) and three distributions of myogenic strength, M(i) (slope of pressure-diameter curve, range -0.05 to -0.4%/mmHg) were evaluated (9 cases). It was found that larger vessels attenuate the myogenic activity of smaller vessels and that myogenic responsiveness is sufficient to achieve autoregulation. When M(i) has a maximum in vessels of 84 microm, the maximum effect of perfusion pressure on active diameter occurs in vessels between 123 and 181 microm, depending on the distribution of R(p). Distribution of resistance and control mechanisms in the coronary arterial tree are important for interpretation of individual vessel responses as observed in vivo.
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Cornelissen et al. (2000) studied Coronary arterial tree myogenic behavior. Myogenic strength and resistance distribution models was evaluated on Myogenic behavior and interaction within the coronary arterial tree. A 10-compartment model of the coronary arterial tree showed that larger vessels attenuate smaller vessel myogenic activity, with maximum perfusion pressure effects occurring in vessels 123-181 µm.
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