Key result
Elevated hs-CRP (>3 mg/L) was associated with coronary vasospasm, but the odds ratios in the highest tertile reduced from 6.01 to 1.48 in women and 6.35 to 2.69 in men if they had hypertension.
Why the study?
How do gender, age, and hypertension interact with hs-CRP levels in the development of coronary vasospasm?
Population
722 Taiwanese patients with or without coronary vasospasm and no obstructive coronary artery disease
Comparison
Elevated high-sensitivity C-reactive protein… vs Lower hs-CRP levels and absence of specific risk…
Design
Cohort
Authors
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Hypertension attenuates hs-CRP–vasospasm association more in women; supports distinct pathogenesis from atherosclerosis and warrants prospective validation.
Observational (n=722)
How do gender, age, and hypertension interact with hs-CRP levels in the development of coronary vasospasm?
Effect estimate: OR 6.01 to 1.48 (women), OR 6.35 to 2.69 (men)
The relationship between hs-CRP and coronary vasospasm differs by gender, and the negative effect of hypertension on vasospasm suggests its pathogenesis differs from that of coronary atherosclerosis.
Hung et al. (2010) conducted an observational in Coronary vasospasm (n=722). High-sensitivity C-reactive protein (hs-CRP) was evaluated on Coronary vasospasm (OR 6.01 to 1.48 (women), OR 6.35 to 2.69 (men)). Elevated hs-CRP (>3 mg/L) was associated with coronary vasospasm, but the odds ratios in the highest tertile reduced from 6.01 to 1.48 in women and 6.35 to 2.69 in men if they had hypertension.
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