Key result
Elevated hsCRP predicted cardiovascular events in 41- and 51-year-old men (HR 1.71; 95% CI 1.1-2.6), while elevated Nt-proBNP predicted events in 61- and 71-year-old women (HR 1.74; 95% CI 1.2-2.5).
Why the study?
Does the predictive value of UACR, hsCRP, and Nt-proBNP for cardiovascular events vary by age and sex in apparently healthy individuals?
Population
1994 apparently healthy individuals aged 41, 51, 61 or 71 years without diabetes, previous stroke or…
Design
Cohort
Follow-up
9.5 years
Authors
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Age- and sex-specific biomarker thresholds may refine CV risk prediction in healthy adults; leaves open validation in prospective cohorts.
Cohort (n=1,994)
Does the predictive value of UACR, hsCRP, and Nt-proBNP for cardiovascular events vary by age and sex in apparently healthy individuals?
Hazard Ratio: 1.71 (95% CI 1.1–2.6)
p-value: p=<0.05
The prognostic utility of hsCRP and NT-proBNP for cardiovascular risk prediction in healthy individuals is significantly modified by sex and age, suggesting a need for demographic-specific risk thresholds.
Olsen et al. (2008) conducted a cohort in Apparently healthy individuals (n=1,994). Elevated hsCRP, Nt-proBNP, and UACR was evaluated on Composite cardiovascular endpoint of cardiovascular death and non-fatal stroke or myocardial infarction (HR 1.71, 95% CI 1.1-2.6, p=<0.05). Elevated hsCRP predicted cardiovascular events in 41- and 51-year-old men (HR 1.71; 95% CI 1.1-2.6), while elevated Nt-proBNP predicted events in 61- and 71-year-old women (HR 1.74; 95% CI 1.2-2.5).
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