November 30, 2020Scandinavian Cardiovascular Journal
Sex- and age-related differences in the predictive capability of circulating biomarkers: from the MONICA 10 cohort
Key result
NT-proBNP, hs-CRP, and suPAR fail to improve cardiovascular death discrimination beyond traditional risk factors.
- n=1,951
Why the study?
The predictive capability of hs-CRP, NT-proBNP, and suPAR for cardiovascular outcomes beyond traditional risk factors in different sex and age groups without known cardiovascular disease was unclear.
Does measurement of circulating biomarkers (hs-CRP, NT-proBNP, suPAR) improve prediction of cardiovascular death beyond traditional risk factors in individuals without known cardiovascular disease?
Population
1951 individuals without known cardiovascular disease stratified by sex and age from the MONICA study
Comparison
Circulating biomarkers (hs-CRP, NT-proBNP, suPAR) versus traditional risk factors
Design
Prospective population-based cohort study
Follow-up
Median 18.5 years
Authors
Discussion
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Implication
Should not yet change CV risk prediction practice; hypothesis-generating for age- and sex-specific biomarker associations.
Study Design
Type
Cohort (n=1,951)
Structured PICO
Does measurement of circulating biomarkers (hs-CRP, NT-proBNP, suPAR) improve prediction of cardiovascular death beyond traditional risk factors in individuals without known cardiovascular disease?
P
Population
1,951 men and women aged 41 to 71 years without known cardiovascular disease, followed for a median of 18.5 years.
E
Exposure
Measurement of circulating biomarkers (hs-CRP, NT-proBNP, and suPAR)
C
Comparator
Traditional risk factors alone
O
Outcome
Death from cardiovascular causeshard clinical
While hs-CRP, NT-proBNP, and suPAR show sex- and age-specific associations with cardiovascular death, they do not significantly improve risk discrimination beyond traditional risk factors in apparently healthy individuals.
Cite This Study
Frary et al. (2020) conducted a cohort in Without known cardiovascular disease (n=1,951). hs-CRP, NT-proBNP, and suPAR vs. Traditional risk factors was evaluated on Death from cardiovascular causes. Over 18.5 years, NT-proBNP, hs-CRP, and suPAR were associated with cardiovascular death in specific subgroups, but none improved discrimination beyond traditional risk factors (p ≥ 0.07).