Key result
Elevated levels of NT-proBNP (HR 1.90; 95% CI 1.58-2.29), hs-CRP, and suPAR predicted cardiovascular death beyond traditional risk factors in apparently healthy individuals.
Why the study?
It was unclear whether hs-CRP, NT-proBNP, and suPAR provide incremental prognostic value for predicting cardiovascular morbidity and mortality beyond traditional risk factors in apparently healthy individuals.
Do hs-CRP, NT-proBNP, and suPAR improve cardiovascular risk stratification beyond traditional risk factors in apparently healthy individuals?
Population
1951 apparently healthy individuals aged 41, 51, 61, or 71 years from the MONICA 10 cohort
Comparison
hs-CRP, NT-proBNP, and suPAR added to traditional risk factors vs traditional risk factors alone
Design
Prospective population-based cohort study
Follow-up
Median 18.5 years
Authors
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Should not yet change primary-prevention practice; leaves open whether these biomarkers warrant inclusion in contemporary risk models.
Cohort (n=1,951)
Do hs-CRP, NT-proBNP, and suPAR improve cardiovascular risk stratification beyond traditional risk factors in apparently healthy individuals?
Hazard Ratio: 1.9 (95% CI 1.58–2.29)
p-value: p=<0.001
NT-proBNP, hs-CRP, and suPAR are associated with long-term cardiovascular mortality in healthy individuals, with NT-proBNP providing significant incremental prognostic value beyond traditional risk factors.
Frary et al. (2019) conducted a cohort in apparently healthy individuals (n=1,951). hs-CRP, NT-proBNP, and suPAR vs. traditional risk factors was evaluated on death from cardiovascular causes (HR 1.90, 95% CI 1.58-2.29, p=<0.001). Elevated levels of NT-proBNP (HR 1.90; 95% CI 1.58-2.29), hs-CRP, and suPAR predicted cardiovascular death beyond traditional risk factors in apparently healthy individuals.
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