Key result
Hemodialysis patients exhibited significantly impaired heart rate variability compared to healthy controls (median SDNN 15.5 ms vs 34.0 ms, p<0.01), which was not related to chronic inflammation.
Why the study?
Does autonomic nervous dysfunction correlate with cellular inflammation in end-stage renal disease patients on hemodialysis?
Population
30 end-stage renal disease patients on hemodialysis and 15 healthy controls, median age 68.0 in HD patients…
Design
Cross-sectional
Authors
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HRV impairment in hemodialysis patients occurs independently of inflammation; leaves open mechanistic links and need for longitudinal studies.
Cross-Sectional (n=45)
No
Does autonomic nervous dysfunction correlate with cellular inflammation in end-stage renal disease patients on hemodialysis?
Absolute Event Rate: 15.5% vs 34%
p-value: p=<0.01
Hemodialysis patients exhibit severe autonomic dysfunction and chronic inflammation, but these two pathophysiological processes do not appear to be directly correlated.
Seibert et al. (2016) conducted a cross-sectional in End-stage renal disease (ESRD) (n=45). Hemodialysis vs. Healthy controls was evaluated on Heart rate variability (SDNN) (p=<0.01). Hemodialysis patients exhibited significantly impaired heart rate variability compared to healthy controls (median SDNN 15.5 ms vs 34.0 ms, p<0.01), which was not related to chronic inflammation.
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