Key result
Severe carotid artery stenosis was associated with decreased functioning on tests of attention, memory, verbal fluency, psychomotor speed, and executive functioning compared to healthy volunteers.
Why the study?
Do patients with severe carotid artery disease exhibit cognitive deficits compared to healthy volunteers prior to carotid endarterectomy?
Case-Control
Do patients with severe carotid artery disease exhibit cognitive deficits compared to healthy volunteers prior to carotid endarterectomy?
Answers are grounded in this paper and cite their sources.
Patients with severe carotid artery disease exhibit significant cognitive deficits across multiple domains prior to surgical intervention, establishing a baseline for evaluating potential post-operative cognitive improvements.
Restorative effects of carotid endarterectomy (CEA) on cognitive functioning in patients with severe atherosclerotic disease presuppose the existence of cognitive deficits prior to the intervention. Thorough examination of this premise received only minor attention. The present study assessed symptomatic and asymptomatic patients with severe unilateral or bilateral stenosis of the carotid arteries one day before CEA. Healthy volunteers with similar demographic characteristics served as control subjects. Patients overall showed decreased functioning on tests of attention, verbal and visual memory, verbal fluency, and psychomotor speed and executive functioning, even after correction for the effects of mood. Simple motor skills and visuospatial functioning were not affected. Patients grouped according to presence and type of previous clinical symptoms and severity of contralateral stenosis only slightly differed from each other. The findings leave open the potential of improving cognitive function after CEA.
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Bossema et al. (2006) conducted a case-control in Carotid Artery Disease. Severe carotid artery stenosis vs. Healthy volunteers was evaluated on Cognitive functioning. Severe carotid artery stenosis was associated with decreased functioning on tests of attention, memory, verbal fluency, psychomotor speed, and executive functioning compared to healthy volunteers.
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