Key result
Carotid endarterectomy is linked to improved 3-month cognitive function in asymptomatic severe carotid stenosis.
Why the study?
Changes in cognitive function following carotid endarterectomy in asymptomatic patients, including those with dementia, were not well characterized.
Does carotid endarterectomy improve cognitive function in asymptomatic patients with and without dementia?
Cohort (n=74)
No
Does carotid endarterectomy improve cognitive function in asymptomatic patients with and without dementia?
Mean Difference: -1.04 (95% CI -1.69–-0.38)
Absolute Event Rate: 18.27% vs 16.88%
p-value: p=0.002
Carotid endarterectomy may offer cognitive improvements at 3 months postoperatively in asymptomatic patients, independent of baseline dementia status.
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CEA was associated with 3-month cognitive gains in asymptomatic patients with or without dementia; leaves open whether revascularization improves cognition beyond stroke prevention.
Gremigni et al. (2016) conducted a cohort in High-degree internal carotid artery stenosis (n=74). Carotid Endarterectomy vs. Pre-operative baseline was evaluated on Change in cognitive function measured by the 26-points Itel-MMSE at 3 months (MD -1.04, 95% CI -1.69 to -0.38, p=0.002). Carotid endarterectomy significantly improved cognitive function at 3 months postoperatively in asymptomatic patients with high-degree stenosis (adjusted mean difference -1.04, p=0.002).
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