Key result
BNP administration following cardio-pulmonary bypass in pigs eliminated the need for catecholamine support (0% vs 70% in control) and significantly improved hemodynamics.
Why the study?
Does BNP administration improve hemodynamics and reduce the need for catecholamines following cardio-pulmonary bypass in a pig model?
Does BNP administration improve hemodynamics and reduce the need for catecholamines following cardio-pulmonary bypass in a pig model?
In a porcine model of cardiopulmonary bypass, BNP administration significantly improved hemodynamics and eliminated the need for catecholamine support.
May support human CPB trials; leaves open translation from porcine model.
OBJECTIVE: The pharmacologic properties of Brain natriuretic peptide make it a favourable substance to use after cardiac operations. The goal of this study was to evaluate the effect of BNP following cardio-pulmonary bypass (CPB). METHOD: Nineteen pigs were operated on using CPB. One group received BNP and the control group received placebo. A 30-minute ischemic episode was simulated. Following declamping, BNP was administered by an IV bolus, followed by an infusion for 60 minutes. Hemodynamic and clinical chemistry parameters were documented, as well as the amount of catecholamines. RESULTS: The Cardiac output and Cardiac Index in the BNP group were significantly higher 60 minutes after ending CPB. Seven of ten animals in the control group needed catecholamines at the end of the experiment, whereas none of the animals in the BNP group did at this juncture. Creatine kinase and Lactate were significantly lower. CONCLUSION: BNP is a well-tolerated agent that could present a new treatment option for heart failure following cardiac surgery. Hemodynamics are greatly improved with almost no need for pharmacological support.
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Bail et al. (2007) studied Cardio-pulmonary bypass (CPB) (n=19). Brain natriuretic peptide (BNP) vs. Placebo was evaluated on Need for catecholamines at the end of the experiment. BNP administration following cardio-pulmonary bypass in pigs eliminated the need for catecholamine support (0% vs 70% in control) and significantly improved hemodynamics.
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