Key result
Higher baseline BNP predicts new-onset AF, inotropic support, and IABP requirement after isolated CABG.
Why the study?
Does preoperative BNP level predict postoperative adverse outcomes in patients undergoing first-time elective CABG?
Population
85 patients undergoing first-time elective isolated on-pump coronary artery bypass grafting (CABG)
Design
Cohort
Follow-up
postoperative period
Authors
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Preoperative BNP may aid risk prediction after CABG; hypothesis-generating and requires prospective validation before clinical use.
Observational (n=85)
No
Does preoperative BNP level predict postoperative adverse outcomes in patients undergoing first-time elective CABG?
Effect estimate: AUC 0.70 (95% CI 0.559-0.837)
Absolute Event Rate: 197% vs 65%
p-value: p=0.006
Preoperative BNP levels can serve as a useful predictive biomarker for postoperative complications, including atrial fibrillation and the need for hemodynamic support, in patients undergoing elective CABG.
Türk et al. (2008) conducted an observational in Coronary artery disease requiring CABG (n=85). Preoperative plasma Brain Natriuretic Peptide (BNP) level vs. Lower preoperative BNP levels was evaluated on Postoperative new-onset atrial fibrillation (AUC 0.70, 95% CI 0.559-0.837, p=0.006). Higher baseline plasma BNP concentration predicted postoperative new-onset atrial fibrillation (AUC 0.70), need for inotropic support (AUC 0.70), and IABP requirement (AUC 0.79) after isolated CABG.
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