Key result
Preoperative BNP > 100 pg/ml is linked to ~13-fold greater risk of prolonged ventilation after OPCAB.
Why the study?
Does elevated preoperative BNP predict prolonged ventilation and ICU stay in patients undergoing off-pump coronary artery bypass?
Cohort (n=112)
Does elevated preoperative BNP predict prolonged ventilation and ICU stay in patients undergoing off-pump coronary artery bypass?
Odds Ratio: 13.33 (95% CI 1.42–125.03)
Elevated baseline BNP (>100 pg/ml) before off-pump CABG is a strong independent predictor of prolonged mechanical ventilation and ICU stay.
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May inform preoperative risk assessment in OPCAB; leaves open prospective validation before guiding interventions.
Wang et al. (2010) conducted a cohort in Coronary artery disease requiring off-pump coronary artery bypass (OPCAB) (n=112). Preoperative BNP level > 100 pg/ml vs. Preoperative BNP level ≤ 100 pg/ml was evaluated on Ventilation > 24 hours (OR 13.33, 95% CI 1.42-125.03). Preoperative BNP > 100 pg/ml was an independent risk factor for ventilation > 24 hours (OR 13.33; 95% CI 1.42-125.03) and ICU stay > 72 hours (OR 3.01; 95% CI 1.09-8.33) after OPCAB.
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