Effectiveness of an educational program on nurses’ knowledge of central line-associated bloodstream infection prevention: A quasi-experimental study

Background: Central venous catheters are frequently used in the acute care settings but are associated with a significant risk of central line-associated bloodstream infections (CLABSIs). Despite the availability of evidence-based CLABSI prevention bundles, knowledge gaps and inconsistent adherence among nurses remain common contributors to rising infection rates. The study aims to evaluate the effectiveness of an educational intervention in improving nurses’ knowledge of central line care and CLABSI prevention. Methods: This quasi-experimental one-group pretest–posttest study was conducted among registered nurses working on two medical-surgical units in a teaching hospital. A voluntary educational program on CLABSI prevention was delivered over 2 days. Participants completed a 10-item multiple-choice pretest before the session and the same posttest was administered immediately after. Scores were compared using paired t -test analysis, with statistical significance set at P < 0.05. Results: Forty nurses participated in the program. The mean pretest score was 64.19 (standard deviation [SD] =13.02), which increased significantly to a mean posttest score of 81.38 (SD = 10.96) after the intervention ( P = 0.000). The proportion of participants achieving a passing score (≥70%) increased from 35% at baseline to 82.5% postintervention. Conclusion: The educational program significantly improved nurses’ knowledge of central line care and CLABSI prevention. Regular, structured training may enhance adherence to evidence-based practices, strengthen patient safety, and reduce CLABSI-related morbidity and healthcare costs. Further research should evaluate long-term knowledge retention and the impact of such educational interventions on actual CLABSI rates.