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This study aims to investigate the role of sFRP1 in melanoma progression and evaluate the effects of WAY-316606.

May 27, 2026CancersOpen Access

Targeting sFRP1 with WAY-316606 Suppresses Proliferation, Migration, and Invasion in Metastatic Melanoma

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This study aims to investigate the role of sFRP1 in melanoma progression and evaluate the effects of WAY-316606.
Quantification of sFRP1 expression in metastatic melanoma cell lines, xenografts, and TCGA datasets.
Assessment of WAY-316606's anti-tumor effects using WST assays, flow cytometry, and quantitative PCR.
Evaluation of cell viability, migration, invasion, and expression of extracellular matrix-related genes.
sFRP1 expression was elevated in melanoma, correlating with poor overall survival.
WAY-316606 reduced melanoma cell viability and induced G1 phase cell cycle arrest.
WAY-316606 diminished migration and invasion of melanoma cells with downregulation of ECM remodeling genes.

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Randomized trial investigates WAY-316606's impact on melanoma invasion, indicating potential therapeutic benefits.

Kim et al. (2026) studied this question.

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