Pharmacological Effects and Safety Research Progress of the Ten Gui Herbs of Guangxi

The "Ten Gui Herbs" represent the core group of authentic medicinal materials from Guangxi, comprising ten characteristic Lingnan herbs: Cinnamomi Cortex (Rougui), Siraitiae Fructus (Luohanguo), Anisi Stellati Fructus (Bajiaohuixiang), Curcumae Kwangsiensis Rhizoma (Guangxi Ezhu), Longan Arillus (Longyanrou), Sophorae Tonkinensis Radix et Rhizoma (Shandougen), Spatholobi Caulis (Jixueteng), Abri Cantoniensis Herba (Jigucao), Zanthoxyli Nitidi Radix (Liangmianzhen), and Pheretima (Guang Dilong). This study systematically reviews the current research status on the chemical composition, pharmacological effects, and safety of the "Ten Gui Herbs," providing a scientific basis for their rational clinical use, new drug development, and dietary therapy promotion. Research indicates that the "Ten Gui Herbs" possess a rich and diverse array of chemical components, including volatile oils, flavonoids, triterpenoids, alkaloids, and other active substances. Their pharmacological effects are extensive, covering cardiovascular protection, immune regulation, anti-inflammatory and anti-tumor activities, metabolic regulation, and other fields, demonstrating broad application prospects. However, safety studies remain unbalanced, with insufficient research on the toxic mechanisms and clinical risk assessment for some herbs. Future efforts should strengthen in-depth research on the pharmacodynamic material basis, mechanisms of action, and safety evaluations to promote the standardized application and industrial development of the "Ten Gui Herbs."