Key result
Bisoprolol improved cardiac function and remodeling in heart failure rats by promoting cardiac angiogenesis via the VEGF signaling pathway, an effect counteracted by VEGF inhibition.
Why the study?
Does VEGF blockade prevent the beneficial effects of bisoprolol on cardiac function, angiogenesis, and remodeling in a rat model of heart failure?
Population
Rats with surgically induced myocardial infarction (heart failure model), 8 weeks post-MI
Comparison
Bisoprolol vs Vehicle
Design
Preclinical, randomized
Follow-up
10 weeks
Authors
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Supports VEGF-angiogenesis mechanism in experimental HF; leaves open translation to human therapy.
Does VEGF blockade prevent the beneficial effects of bisoprolol on cardiac function, angiogenesis, and remodeling in a rat model of heart failure?
The beneficial effects of beta-blockers on cardiac function and remodeling in heart failure are mediated, at least in part, by the promotion of cardiac angiogenesis via the VEGF signaling pathway.
Rengo et al. (2013) studied Heart failure post-myocardial infarction. Bisoprolol +/- adenoviral vector encoding a decoy VEGF receptor (Ad-Flk) vs. Vehicle +/- control adenovirus (Ad-C) was evaluated on Cardiac function, angiogenesis, and remodeling. Bisoprolol improved cardiac function and remodeling in heart failure rats by promoting cardiac angiogenesis via the VEGF signaling pathway, an effect counteracted by VEGF inhibition.
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