Key result
Protein restriction, tight control of blood sugar and blood pressure, and ACE inhibitors independently reduce microalbuminuria and preserve renal function in early diabetic kidney disease.
Why the study?
Do protein restriction, tight glycemic and blood pressure control, and ACE inhibitors reduce microalbuminuria and preserve renal function in patients with early diabetic nephropathy?
Do protein restriction, tight glycemic and blood pressure control, and ACE inhibitors reduce microalbuminuria and preserve renal function in patients with early diabetic nephropathy?
This review highlights that early detection of diabetic nephropathy via microalbuminuria screening allows for interventions like ACE inhibitors and tight metabolic control to preserve renal function.
May support early multifactorial intervention in diabetic nephropathy; leaves open confirmatory RCTs on independent effects.
Diabetic nephropathy affects approximately 35% of patients with insulin-dependent diabetes mellitus and about 5% to 10% of patients with non-insulin-dependent diabetes mellitus. Diabetic kidney disease can be detected early by special methods that measure microalbuminuria in the range of 15 to 140 micrograms/min or 0.02 to 0.20 g/d. Specific strategies have been proved beneficial in patients with this early diabetic kidney disease, also called "incipient nephropathy." Protein restriction, tight control of blood sugar and blood pressure, and specific therapy with angiotensin-converting enzyme inhibitors have been shown independently to reduce microalbuminuria and preserve renal function in these patients. We review the pathogenesis of diabetic kidney disease and discuss the effects of these treatment strategies on the renal, cardiovascular, metabolic, and other abnormalities found in early (incipient) and overt diabetic nephropathy.
No takes yet. Share an insight, caveat, or question.
Michael J. Carella (1994) conducted a review in Diabetic nephropathy. Protein restriction, tight control of blood sugar and blood pressure, and ACE inhibitors was evaluated. Protein restriction, tight control of blood sugar and blood pressure, and ACE inhibitors independently reduce microalbuminuria and preserve renal function in early diabetic kidney disease.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: