Key result
Endovascular injury significantly upregulated proinflammatory adipocytokines and downregulated adiponectin in periadventitial fat, mediated by TNF-alpha to augment neointimal hyperplasia.
Endovascular injury induces rapid, TNF-alpha-mediated inflammatory phenotypic changes in perivascular adipose tissue, which may contribute to neointimal hyperplasia after angioplasty.
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Highlights perivascular fat inflammation as a restenosis modulator; hypothesis-generating, needs human validation before targeting.
Takaoka et al. (2010) studied Endovascular injury. Endovascular injury was evaluated on Expression of proinflammatory adipocytokines and adiponectin, and neointimal hyperplasia. Endovascular injury significantly upregulated proinflammatory adipocytokines and downregulated adiponectin in periadventitial fat, mediated by TNF-alpha to augment neointimal hyperplasia.
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