Key result
Applying atropine after acetylcholine markedly attenuated atrial fibrillation duration from 17 to 2 minutes (P<0.05), whereas initial atropine application had no significant effect.
Why the study?
Does the sequence of atropine and acetylcholine administration alter atrial fibrillation duration in a canine model?
Population
22 pentobarbital anesthetized dogs with isolated atrial appendages via thoracotomy
Comparison
Application of Atropine and Acetylcholine in… vs Different sequence of drug application
Design
Preclinical
Authors
Loading...
Atropine-acetylcholine sequence may affect atrial fibrillation duration in canines; hypothesis-generating for M2 allostery without clinical translation.
Does the sequence of atropine and acetylcholine administration alter atrial fibrillation duration in a canine model?
Absolute Event Rate: 2% vs 17%
p-value: p=<0.05
Atropine exhibits paradoxical effects on atrial fibrillation inducibility depending on the sequence of administration with acetylcholine, suggesting allosteric binding at the M2 receptor.
Liu et al. (2017) studied Atrial fibrillation (n=22). Atropine and Acetylcholine vs. Baseline or alternate sequence was evaluated on Atrial fibrillation (AF) duration (p=<0.05). Applying atropine after acetylcholine markedly attenuated atrial fibrillation duration from 17 to 2 minutes (P<0.05), whereas initial atropine application had no significant effect.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: