Key result
In denervated dogs, atropine significantly increased the train-of-pulses atrial fibrillation threshold from 4.7 to 32.3 mA (P<0.001), suggesting local acetylcholine release lowers the threshold.
Why the study?
Does atropine administration affect the atrial fibrillation threshold measured by a train of stimuli in denervated dogs?
Population
16 open-chest dogs anesthetized with alpha-chloralose, denervated by bilateral transection of the stellates…
Comparison
Atropine administered after beta-adrenergic… vs Baseline atrial fibrillation threshold before…
Design
Preclinical
Authors
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Atropine raises AF threshold in denervated dogs; leaves open whether local acetylcholine modulates human AF vulnerability.
Does atropine administration affect the atrial fibrillation threshold measured by a train of stimuli in denervated dogs?
Absolute Event Rate: 32.3% vs 4.7%
p-value: p=<0.001
A train of electrical stimuli lowers the atrial fibrillation threshold by liberating local stores of acetylcholine, which shortens atrial repolarization time.
Euler et al. (1987) studied Atrial fibrillation threshold (n=16). Atropine vs. Baseline (before atropine) was evaluated on Train-of-pulses atrial fibrillation threshold (AFT) (p=<0.001). In denervated dogs, atropine significantly increased the train-of-pulses atrial fibrillation threshold from 4.7 to 32.3 mA (P<0.001), suggesting local acetylcholine release lowers the threshold.
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