Why the study?
Is angiotensin converting enzyme activity altered in specific brain regions of patients with Alzheimer's disease compared to age-matched controls?
Is angiotensin converting enzyme activity altered in specific brain regions of patients with Alzheimer's disease compared to age-matched controls?
Angiotensin converting enzyme activity is significantly increased in specific brain regions, including the hippocampus and frontal cortex, in patients with Alzheimer's disease.
ACE elevation in AD brain regions is hypothesis-generating; leaves open causal role and therapeutic relevance.
The activity of the dipeptidyl carboxypeptidase, angiotensin converting enzyme, was assayed in several brain regions of patients dying with Alzheimer's disease and compared to that of appropriately age-matched controls. Enzyme activity was found to be elevated by 44% and 41% in the medial hippocampus and parahippocampal gyrus, respectively, and by 27% and 29% in the frontal cortex (area 10 of Brodman) and caudate nucleus, respectively, in Alzheimer's disease patients. Converting enzyme activity did not differ from controls in the nucleus accumbens, substantia nigra, temporal cortex, anterior or posterior hippocampus, amydgala, and septal nuclei.
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Arregui et al. (1982) studied this question.
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