Key result
Highest hs-CRP quintile linked to ~87% higher nonfatal stroke risk vs. lowest quintile.
Why the study?
Does elevated baseline hs-CRP predict nonfatal stroke incidence in African Americans?
Population
African Americans enrolled in the Jackson Heart Study (JHS) in the United States
Comparison
High baseline high-sensitivity C-reactive… vs Low baseline hs-CRP levels
Design
Cohort
Authors
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High baseline hs-CRP levels (≥0.0676 mg/L) are independently associated with an increased risk of nonfatal stroke among African Americans.
Cohort
Does elevated baseline hs-CRP predict nonfatal stroke incidence in African Americans?
Hazard Ratio: 1.87 (95% CI 1.17–2.98)
High baseline hs-CRP levels (≥0.0676 mg/L) are independently associated with an increased risk of nonfatal stroke among African Americans.
Hayes et al. (2025) conducted a cohort in Stroke. High-sensitivity C-reactive protein (hs-CRP) quintile 5 (≥0.0676 mg/L) vs. hs-CRP quintile 1 (0.0084 mg/L) was evaluated on Nonfatal stroke incidence (HR 1.87, 95% CI 1.17-2.98). The highest quintile of hs-CRP (≥0.0676 mg/L) was independently associated with an increased risk of nonfatal stroke compared with the lowest quintile (HR 1.87; 95% CI 1.17-2.98).
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