Key result
Platelets of patients with type II diabetes released significantly more PAI-1 than platelets of healthy subjects after 180 minutes (61.8 vs 35.9 ng/ml; P<0.005).
Why the study?
Is platelet PAI-1 release increased in patients with type II diabetes compared to healthy controls?
Case-Control (n=43)
Is platelet PAI-1 release increased in patients with type II diabetes compared to healthy controls?
Patients with type II diabetes exhibit significantly higher platelet PAI-1 release compared to healthy controls, which may contribute to their increased thrombotic risk.
Answers are grounded in this paper and cite their sources.
May heighten thrombotic risk in type 2 diabetes; hypothesis-generating for PAI-1-targeted interventions.
OBJECTIVE: To compare platelet plasminogen activator inhibitor 1 (PAI-1) release in type II diabetic patients and healthy control subjects. RESEARCH DESIGN AND METHODS: We studied a group of 27 diabetic patients and a group of 16 nondiabetic control subjects. Whole-blood platelet aggregation, defined as a decrease in platelet count during shaking (180 rpm) of blood samples at 37 degrees C, and plasma PAI-1 antigen concentrations were measured in parallel at time 0, 7.5, 15, 30, 60, 120, and 180 min. RESULTS: Platelet aggregation did not differ significantly between the two groups at any time period. However, the increase in plasma PAI-1 antigen concentration over basal levels at time 0 was higher for the group of diabetic patients when compared with their matched control subjects. The increment of PAI-1 antigen was 61.8 +/- 29.4 vs. 35.9 +/- 13.4 ng/ml (P < 0.005, means +/- SD) after 180 min for the diabetic and control subjects, respectively. Platelet PAI-1 release was correlated to very-low-density lipoprotein cholesterol and triglyceride plasma levels, but not to HbA1c levels. CONCLUSIONS: Platelets of patients with type II diabetes release significantly more PAI-1 than platelets of healthy subjects at the same level of platelet aggregation. This may contribute to enhanced thrombosis in diabetes.
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Jokl et al. (1995) conducted a case-control in Type II Diabetes (n=43). Type II Diabetes vs. Healthy control subjects was evaluated on Increment of plasma PAI-1 antigen concentration over basal levels after 180 min (p=< 0.005). Platelets of patients with type II diabetes released significantly more PAI-1 than platelets of healthy subjects after 180 minutes (61.8 vs 35.9 ng/ml; P<0.005).
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