Key result
HDL-C <1 mmol/L was associated with a higher frequency of high-sensitivity troponin T >50 ng/L compared to HDL-C ≥1 mmol/L (OR 1.84; 95% CI 1.03-3.32).
Why the study?
Are HDL-C values independently associated with cardiac troponin concentrations in patients undergoing routine cardiovascular risk assessment?
Observational
Yes
Are HDL-C values independently associated with cardiac troponin concentrations in patients undergoing routine cardiovascular risk assessment?
Effect estimate: OR 1.84 (95% CI 1.03-3.32)
p-value: p=0.032
Higher HDL-C values are independently associated with lower concentrations of cardiac troponins, suggesting an inverse relationship between HDL-C and subclinical myocardial injury.
Low HDL-C may signal subclinical injury in risk assessment; leaves open causal effects on troponin levels.
BACKGROUND: This retrospective study was planned to establish potential associations between circulating values of cardiac troponins and those of conventional blood lipids. METHODS: The study population consisted of patients attending an inpatient clinic of the University Hospital of Verona during the year 2015 as part of routine cardiovascular risk assessment. No exclusion criteria were applied. Serum lipids including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG) were measured using reference enzymatic techniques, whereas troponin T (TnT) was measured using a high-sensitivity (HS) immunoassay. A second analysis was also performed in the General Hospital of Verona, extracting data from the local laboratory database of all patients in whom troponin I (TnI) and blood lipids were simultaneously measured during the same year. RESULTS: In univariate analysis, HS-TnT was found to be associated with age, sex, TC, LDL-C, HDL-C, but not with TG. In multivariate linear regression analysis, age (positive correlation; P<0.001) and HDL-C (negative correlation; P=0.032) remained significantly associated with HS-TnT. The frequency of HS-TnT values >50 ng/L was higher in subjects with HDL-C <1 mmol/L than in those with HDL-C ≥1 mmol/L [odds ratio (OR), 1.84; 95% confidence interval (CI), 1.03-3.32]. The frequency of HS-TnT values >50 ng/L was also higher in elderly subjects than in younger ones (OR, 2.10; 95% CI, 1.15-3.84). The combination of age and HDL-C explained 35% of overall variability of TnT concentration. In the second analysis, HDL-C was also found to be an independent and negative predictor of TnI in multivariate linear regression analysis (P=0.010). The combination of age and HDL-C explained approximately 28% of the overall variability of TnI concentration. CONCLUSIONS: Our study suggests that HDL-C values inversely predict cardiac troponins concentration irrespective of age, sex and other blood lipids.
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Lippi et al. (2016) conducted an observational in Cardiovascular risk assessment. High-density lipoprotein cholesterol (HDL-C) was evaluated on High-sensitivity troponin T (HS-TnT) values >50 ng/L (OR 1.84, 95% CI 1.03-3.32, p=0.032). HDL-C <1 mmol/L was associated with a higher frequency of high-sensitivity troponin T >50 ng/L compared to HDL-C ≥1 mmol/L (OR 1.84; 95% CI 1.03-3.32).
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