Why the study?
Are elevated troponin T levels associated with altered lipid profiles in patients admitted with acute myocardial infarction?
Are elevated troponin T levels associated with altered lipid profiles in patients admitted with acute myocardial infarction?
Elevated troponin T levels in patients with suspected myocardial infarction are positively correlated with total cholesterol, triglycerides, LDL, and TC/HC ratio, and negatively correlated with HDL.
Troponin T may mark lipid changes in acute MI; leaves open causal links and prognostic utility pending prospective validation.
OBJECTIVE: To determine whether elevated levels of troponin T are associated with altered lipid profile. METHODS: Data were collected from 205 patients each of whom presented elevated troponin T levels. RESULTS: 195 patients presented with suspected myocardial infarction, 10 patients did not. Of which 68 had medium, 107 high and 20 presented with very high troponin T levels. The proportions were significantly different (p = 0.000215). Regression analysis showed that troponin T level was a useful quadratic predictor of total cholesterol (p = 0.000), triglycerides (p = 0.003), and low density cholesterol (p = 0.000); and a useful linear predictor of TC/HC ratio (p = 0.001). CONCLUSIONS: The occurrence of myocardial infarction is associated with elevated troponin T levels; troponin T is positively correlated with total cholesterol, triglycerides, LDL and TC/HC ratio and negatively correlated with HDL. TC/HC ratio was not found to be a useful predictor of the likelihood of MI.
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Nayak et al. (2009) studied this question.
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