Key result
Pharmacist interventions increase odds of achieving thrombolytic DTN times ≤45 minutes by ~169%.
Why the study?
Pharmacists are well-placed to support stroke prevention, but their role and impact in this area remain ill-defined.
Do pharmacist interventions improve health-related outcomes and door-to-needle times in patients requiring primary and secondary prevention of stroke?
Population
31 studies on pharmacist interventions in primary and secondary ischaemic stroke prevention
Comparison
Pharmacist interventions vs comparator or standard care
Design
Systematic review and meta-analysis
Authors
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Supports incorporating pharmacists into emergency stroke teams to meet DTN targets; extends evidence for multidisciplinary thrombolysis optimization.
Meta-Analysis
Do pharmacist interventions improve health-related outcomes and door-to-needle times in patients requiring primary and secondary prevention of stroke?
Effect estimate: OR 2.69 (95% CI 1.95-3.72)
p-value: p=<0.001
Pharmacist interventions across the stroke treatment pathway, particularly in emergency care, significantly improve door-to-needle times for thrombolytic therapy.
Al-Qahtani et al. (2022) conducted a meta-analysis in Ischaemic stroke prevention. Pharmacist interventions was evaluated on Achieving thrombolytic therapy door to needle (DTN) times ≤45 min (OR 2.69, 95% CI 1.95-3.72, p=<0.001). Pharmacist interventions in emergency care significantly improved the odds of achieving thrombolytic therapy door to needle times ≤45 min (OR 2.69; 95% CI 1.95-3.72; p<0.001).
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