Key result
The muscle duplex approach reveals that myocardial heterogeneity is a physiological attribute of cardiac function, with mechano-electric feedback tuning local contractility to global demand.
This review highlights the foundational work of V.S. Markhasin on myocardial mechano-electric heterogeneity and the muscle duplex model, emphasizing the dynamic adjustment of regional electrical and mechanical properties in cardiac function.
Positions myocardial heterogeneity as physiological; leaves open clinical translation of mechano-electric feedback models.
Myocardial heterogeneity is well appreciated and widely documented, from sub-cellular to organ levels. This paper reviews significant achievements of the group, led by Professor Vladimir S. Markhasin, Russia, who was one of the pioneers in studying and interpreting the relevance of cardiac functional heterogeneity.
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Solovyova et al. (2015) conducted a review in Myocardial heterogeneity. The muscle duplex approach reveals that myocardial heterogeneity is a physiological attribute of cardiac function, with mechano-electric feedback tuning local contractility to global demand.
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