What is the clinical evidence from this study?

Study design: Review. Population: Ambulatory blood pressure variability.

What question did this study set out to answer?

To review the clinical relevance, reliability, measurement techniques, predictors, and therapeutic implications of ambulatory blood pressure variability.

December 7, 2016Blood Pressure MonitoringOpen Access

Ambulatory blood pressure variability

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Key result

Ambulatory blood pressure variability is an independent predictor of cardiovascular disease and mortality, highlighting its potential role in hypertension management.

Design

Review

Authors

MZMatthew J. ZawadzkiUniversity of California, Merced ASAmanda K. SmallUniversity of California, Merced WGWilliam GerinPreventive Cardiology

Discussion

Member takes

Implication

May inform risk stratification; leaves open whether targeting variability improves outcomes.

Key Points

To review the clinical relevance, reliability, measurement techniques, predictors, and therapeutic implications of ambulatory blood pressure variability.
Conducted a conceptual review assessing calculation methodologies, reliability, and clinical outcomes associated with ambulatory blood pressure variability.
Synthesized evidence on behavioral and physiological predictors as well as therapeutic interventions targeting blood pressure fluctuations.
Identified blood pressure variability as an independent predictor of cardiovascular disease and overall mortality beyond standard mean ambulatory pressure measurements.
Determined that momentary physiological assessments and mechanistic studies are essential to clarify the role of pressure fluctuations in hypertension.

PICO

Population

Ambulatory blood pressure variability

Ambulatory blood pressure variability is an underutilized but important independent predictor of cardiovascular disease and mortality that warrants further clinical and research attention.

Limitations

It is not clear whether ABPV offers unique information over and above the ABP mean.
Comparisons between systolic and diastolic ABP, and especially between daytime and night-time ABP, are lacking.
Evidence for the potential of nonpharmacological interventions to lower ABPV is lacking.
It is unclear whether elevated variability is a contributor to the development and progression of the disease, a byproduct, or wholly epiphenomenal.

Cite This Study

Zawadzki et al. (2016) conducted a review in Ambulatory blood pressure variability. Ambulatory blood pressure variability is an independent predictor of cardiovascular disease and mortality, highlighting its potential role in hypertension management.

synapsesocial.com/papers/6a16db1fc7240d1a707bb39e https://doi.org/10.1097/mbp.0000000000000230

Topics

Hypertension management

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Ambulatory blood pressure variability

Discussion

Member takes

Implication

Key Points

PICO

Limitations

Cite This Study

Topics

Ambulatory blood pressure variability

Discussion

Member takes

Implication

Key Points

PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider